[{"data":1,"prerenderedAt":189},["ShallowReactive",2],{"content-route-/en/research/candida-diet-gut-mycobiome-2023":3},{"state":4,"owner":4,"route":5,"locale":6,"template":7,"content":21,"projection":171,"alternates":180},"target","/en/research/candida-diet-gut-mycobiome-2023","en-US",{"kind":8,"family":8,"sectionKeys":9},"research-summary",[10,11,12,13,14,15,16,17,18,19,20],"bottom-line","why-source-matters","study-population","tested","results","applicability","limitations","contribution","practical-change","funding-conflicts","source",{"kind":8,"title":22,"description":23,"firstPublished":24,"evidenceAsOf":24,"lastUpdated":24,"changeNote":25,"research":26,"relations":56,"body":60},"Candida, diet, and the gut mycobiome: a 2023 study","A 72-day feeding study tracked fungi in stool; it did not test Candida symptoms, candidiasis, or whether a diet treats Candida.","2026-10-08","Published a contextual summary of short-term dietary mycobiome findings; no Candida-related claim or practical guidance changed.",{"sourceId":27,"studyType":28,"population":29,"sampleScale":30,"contribution":31,"contributionRationale":32,"relatedEvidenceMap":33,"funding":34,"conflicts":35,"paperDate":36,"results":37,"applicability":40,"limitations":45,"practicalChange":55},"tian-macronutrient-gut-mycobiome-2023","Randomized-sequence controlled-feeding crossover series with an exploratory secondary fecal ITS2 mycobiome analysis","30 adults aged 22–34 enrolled at Westlake University in Hangzhou, China; 28 completers were analyzed.","30 enrolled; 28 completed and analyzed; 317 fecal samples were reported across the 72-day series.","contextual","This study adds narrow human evidence that short-term macronutrient patterns can coincide with changes in fecal fungal-community measures. It did not test disease or treatment outcomes, so it does not change related clinical claims or practical guidance.","/en/research/evidence/broad-candida-claims","Funders were the Zhejiang Province Key of Traditional Chinese Medicine Modernization (2022ZX004); National Key R&D Program of China (2022YFA1303900); National Natural Science Foundation of China (82103826 and 82073529); Zhejiang Provincial Natural Science Foundation (LQ21H260002); Westlake Laboratory of Life Sciences and Biomedicine (202208012); and Zhejiang's Pioneer and Leading Goose R&D Program (2022C03102).","The authors declared no conflict of interest.","2023-04-29",[38,39],"The analysis included 28 completers and 317 fecal samples. Supplementary Table S4 reports Candida detection in 96.4% of participants and 52.4% of samples; the main text also says Candida was detected in 16 participants, an unresolved inconsistency with the 96.4% figure.","The Results section reports increased group-level fecal alpha diversity after HC periods (p\u003C0.05) and a significant pre/post beta-diversity difference after the HC intervention (p\u003C0.05); the Discussion and Conclusion state more broadly that both HC and LC may affect fungal community structure. These are not a direct HC-versus-LC comparison. Candida was not listed among genera with a significant pre/post relative-abundance change within either diet period; no Candida-specific effect estimate was reported.",{"appliesTo":41,"doesNotApplyTo":43},[42],"Short-term fecal fungal-community measures during the specific controlled macronutrient patterns studied in young adults in Hangzhou, China",[44],"Diagnosing candidiasis from stool detection, fungal eradication, symptom relief, a sugar-only effect, or an individual diet or treatment decision",[46,49,52],{"finding":47,"limitation":48},"The paper reports Candida detection in 16 participants in the text, 96.4% of participants in Supplementary Table S4, and 52.4% of samples.","The participant figures do not reconcile for 28 analyzed participants and the authors do not resolve the discrepancy. Sample prevalence has a different denominator. Candida's absence from the reported differential-abundance list does not establish no effect.",{"finding":50,"limitation":51},"Fecal diversity and genus-level relative abundance changed during the dietary periods.","ITS2 sequencing and relative abundance do not measure absolute fungal burden or establish infection; the study did not assess Candida symptoms, candidiasis, eradication, or health benefit.",{"finding":53,"limitation":54},"The study analyzed 28 completers from 30 enrolled adults during six-day dietary periods in a 72-day series.","The young, single-university sample was small, follow-up was short, and two enrollees did not complete for reasons not reported here. The exploratory taxon analysis used an FDR threshold below 0.1; adverse outcomes were not reported.","No practical change. This microbiome study does not show that a high- or low-carbohydrate diet treats Candida, changes candidiasis, or should guide an individual's care.",[57],{"group":58,"route":33,"label":59},"evidence","Broad Candida claims evidence map",{"type":61,"value":62,"toc":167},"minimark",[63,71,82,88,94,106,115,127,136,142,148],[64,65,67],"content-section",{"section-key":10,"title":66},"Bottom line",[68,69,70],"p",{},"This small feeding study tracked stool fungi during short high- and low-carbohydrate periods. It did not test whether either diet treats Candida-related symptoms or disease.",[64,72,74],{"section-key":11,"title":73},"Why this source matters",[68,75,76,77,81],{},"It is a controlled feeding study that measured fecal fungi and reported ",[78,79,80],"em",{},"Candida"," detection, but it answers a microbiome question rather than whether diet affects candidiasis.",[64,83,85],{"section-key":12,"title":84},"Study and population",[68,86,87],{},"Thirty adults aged 22–34 enrolled at Westlake University in Hangzhou, China. Twenty-eight completed and were analyzed; the study reported 317 fecal samples.",[64,89,91],{"section-key":13,"title":90},"What was tested",[68,92,93],{},"Participants received isocaloric high-carbohydrate (HC) diets providing 65–75% of energy from carbohydrate or low-carbohydrate (LC) diets providing 15–25%; both provided 15% protein. The remainder of energy came from fat. Participants followed six-day periods of each diet in randomized order, with six-day washouts across three cycles over 72 days. Grain intake was the main adjusted component, so this was not a sugar-only experiment.",[64,95,97],{"section-key":14,"title":96},"Results",[68,98,99,100,102,103,105],{},"The Results section reports increased group-level fecal alpha diversity after HC periods (p\u003C0.05) and a significant pre/post beta-diversity difference after the HC intervention (p\u003C0.05). The Discussion and Conclusion state more broadly that both HC and LC may affect fungal community structure, without a direct HC-versus-LC comparison. The paper did not list ",[78,101,80],{}," among genera with a significant pre/post relative-abundance change within either diet period. Supplementary Table S4 reports ",[78,104,80],{}," detection in 96.4% of participants and 52.4% of samples, while the main text says 16 participants; the source does not resolve this inconsistency. This omission from the reported list does not establish no effect.",[64,107,109],{"section-key":15,"title":108},"Applicability",[68,110,111,112,114],{},"The results apply to stool fungal-community measures during these specific short, provided diets among young adults in one Chinese university study. They do not diagnose ",[78,113,80],{}," infection, measure symptoms, or show that changing carbohydrate intake benefits a person.",[64,116,118],{"section-key":16,"title":117},"Limitations",[68,119,120,121,123,124,126],{},"Only 28 young adults completed the study, and the diet periods lasted six days. Fecal ITS2 profiles and relative abundance do not measure absolute fungal load or candidiasis. Participant-level ",[78,122,80],{}," prevalence is inconsistent between the text (16 people) and Supplementary Table S4 (96.4%); the sample-level figure is 52.4%. No ",[78,125,80],{},"-specific result by diet, clinical follow-up, or adverse-outcome results were reported.",[64,128,130],{"section-key":17,"title":129},"Contribution to the evidence",[68,131,132,133,135],{},"Contextual. The study shows that some fecal fungal-community measures can differ during short macronutrient-pattern changes. It does not establish a ",[78,134,80],{}," response, disease effect, or treatment benefit.",[64,137,139],{"section-key":18,"title":138},"Practical change",[68,140,141],{},"No practical change. The study does not show that a high- or low-carbohydrate diet treats Candida or should guide an individual's care.",[64,143,145],{"section-key":19,"title":144},"Funding and conflicts",[68,146,147],{},"Funders included Zhejiang Province, China's National Key R&D Program and National Natural Science Foundation, the Zhejiang Provincial Natural Science Foundation, Westlake Laboratory of Life Sciences and Biomedicine, and Zhejiang's Pioneer and Leading Goose R&D Program. The authors declared no conflict of interest.",[64,149,151],{"section-key":20,"title":150},"Source",[68,152,153,160,161,166],{},[154,155,159],"a",{"href":156,"rel":157},"https://pmc.ncbi.nlm.nih.gov/articles/PMC10180985/",[158],"nofollow","Read the original publication at PubMed Central"," (published 29 April 2023; ",[154,162,165],{"href":163,"rel":164},"https://doi.org/10.3390/nu15092152",[158],"DOI: 10.3390/nu15092152",").",{"title":168,"searchDepth":169,"depth":169,"links":170},"",2,[],{"sources":172,"claims":178,"safety":179},[173],{"sourceId":27,"title":174,"canonicalId":175,"canonicalUrl":156,"publisher":176,"sourceType":177,"publicationDate":36,"lastChecked":24},"The Short-Term Variation of Human Gut Mycobiome in Response to Dietary Intervention of Different Macronutrient Distributions","PMID:37432284; DOI:10.3390/nu15092152","Nutrients","randomized-trial",[],[],[181,184,187],{"rel":182,"hreflang":6,"href":183},"alternate","https://candipedia.org/en/research/candida-diet-gut-mycobiome-2023/",{"rel":182,"hreflang":185,"href":186},"pl-PL","https://candipedia.org/pl/research/candida-dieta-mykobiom-jelitowy-2023/",{"rel":182,"hreflang":188,"href":183},"x-default",1791487498268]