[{"data":1,"prerenderedAt":344},["ShallowReactive",2],{"content-route-/en/symptoms-conditions/serious-fungal-infections":3},{"state":4,"owner":4,"route":5,"locale":6,"template":7,"content":14,"projection":93,"alternates":335},"target","/en/symptoms-conditions/serious-fungal-infections","en-US",{"kind":8,"family":9,"sectionKeys":10},"safety-orientation","guidance",[11,12,13],"triggers","care-routes","sources",{"kind":8,"title":15,"description":16,"firstPublished":17,"evidenceAsOf":17,"lastUpdated":17,"changeNote":18,"firstLayer":19,"relations":48,"body":66},"Serious fungal infections — who needs assessment and when","Use observable symptoms and health context to choose routine, prompt, or emergency care without treating them as proof of an invasive fungal infection.","2026-07-15","Complete initial draft based on the serious-or-urgent and US authority packs for Pathway C.",{"question":20,"answer":21,"keyPoints":22,"confidence":26,"applicability":29,"nextSteps":36},"When should a possible fungal infection be assessed as a serious health concern?","Do not try to identify an invasive fungal infection from symptoms or a risk factor. Arrange assessment when a possible fungal problem occurs with weakened immunity, major recent healthcare exposure, unexplained adult oral thrush, pain or difficulty swallowing, or worsening despite treatment; use emergency care for the listed observable emergency features.",[23,24,25],"Serious invasive candidiasis is concentrated in people who are hospitalized, medically complex, or substantially immunocompromised, but risk context alone does not establish an infection.","Fever, chills, swallowing symptoms, or other systemic illness features are not specific to Candida; suspected invasive disease needs clinical assessment and testing, not self-care.","Suspected or confirmed Candida auris infection or colonization belongs in healthcare and infection-control management, not an ordinary self-treatment pathway.",{"summary":27,"rationale":28},"Strong confidence in keeping invasive disease outside self-care and using risk context plus observable care triggers; no symptom list can identify the cause for an individual.","Current CDC guidance, global and IDSA candidiasis guidelines, NIH guidance, and current US care authorities agree that serious fungal disease is nonspecific, risk-dependent, test-dependent, and professionally managed.",{"appliesTo":30,"excludes":33},[31,32],"Children and adults in the United States with a possible fungal symptom and cancer treatment, transplant, HIV, another weakened-immune-system condition or therapy, recent hospitalization, major surgery, an invasive device, critical illness, dialysis, diabetes, or another complex healthcare context.","People with unexplained adult thrush-like mouth changes, pain or difficulty swallowing, a known or suspected infection that is not improving or is worsening, or concern about Candida auris after healthcare exposure.",[34,35],"People with a stable, localized mouth, skin, nail, or foot concern and none of the listed risk or worsening contexts; use the relevant problem-orientation route for assessment rather than assuming invasive disease.","People seeking a diagnosis, probability estimate, or antifungal regimen from symptoms, a photograph, a risk factor, or this page; invasive and healthcare-associated infections require clinical and laboratory assessment.",[37,41,45],{"label":38,"action":39,"route":40},"Contact the treating team","If weakened immunity, cancer treatment, transplant, major healthcare exposure, or an invasive device accompanies a possible fungal symptom, contact the treating healthcare provider and describe the symptom, timing, care exposure, medicines, and any recent treatment response.","/en/start-here/symptoms-now",{"label":42,"action":43,"route":44},"Get prompt reassessment","If a known or suspected infection is not getting better or is getting worse, get medical care immediately and ask whether emergency-department assessment is needed; do not explain worsening with a fungal label.","/en/urgent-help",{"label":46,"action":47,"route":44},"Use emergency care for observable danger","With a known or suspected infection plus clammy skin, confusion, extreme pain, fever with shivering or feeling very cold, a high heart rate or weak pulse, or shortness of breath, call 911 or go to the nearest emergency department now.",[49,53,57,60,63],{"group":50,"route":51,"label":52},"parent","/en/symptoms-conditions","Symptoms & conditions",{"group":54,"route":55,"label":56},"differential","/en/symptoms-conditions/oral-thrush","Oral thrush orientation",{"group":54,"route":58,"label":59},"/en/symptoms-conditions/fungal-skin-infection","Skin problem orientation",{"group":54,"route":61,"label":62},"/en/symptoms-conditions/nail-and-foot-fungal-problems","Nail and foot orientation",{"group":64,"route":44,"label":65},"safety","Urgent help",{"type":67,"value":68,"toc":89},"minimark",[69,77,83],[70,71,73],"content-section",{"section-key":11,"title":72},"Observable reasons to change the care route",[74,75,76],"p",{},"Use the person’s current situation, not a presumed fungal diagnosis. Contact the treating team when a possible fungal symptom occurs with cancer treatment, transplant, HIV, another weakened-immune-system condition or therapy, or when an infection under treatment is not improving. Thrush-like mouth changes or pain or difficulty swallowing in this context need prompt assessment. A person with diabetes should have listed foot or nail changes assessed rather than treating them as proof of fungus. A known or suspected infection that is getting worse needs immediate medical care; clammy skin, confusion, extreme pain, fever with shivering or feeling very cold, a high heart rate or weak pulse, or shortness of breath are emergency triggers in that infection context.",[70,78,80],{"section-key":12,"title":79},"Choose routine, prompt, or emergency care",[74,81,82],{},"For a stable nonemergency concern, contact the treating healthcare provider. If no regular clinician or dentist is available, use HRSA Find a Health Center and ask whether the site provides the needed service. For a known or suspected infection that is not improving or is worsening without the listed emergency features, get medical care immediately and ask whether emergency-department assessment is needed. For the listed emergency features or another immediate medical emergency, call 911 or go to the nearest emergency department now. None of these routes confirms that the cause is fungal.",[70,84,86],{"section-key":13,"title":85},"Why this page cannot establish the cause or recommend self-care",[74,87,88],{},"Current authorities describe invasive candidiasis as a clinician-managed, test-dependent illness concentrated in hospitalized, medically complex, or substantially immunocompromised populations. Its symptoms are nonspecific. Candida auris colonization and infection are distinct and require specialized identification and healthcare infection-control management. Treatment persistence or worsening reopens the diagnosis, site, organism, host risk, exposure, treatment, adherence, and adverse-effect assessment; it does not by itself prove resistance or invasive disease. The canonical claim and safety records above provide the source, check, and expiry dates for every care statement on this draft.",{"title":90,"searchDepth":91,"depth":91,"links":92},"",2,[],{"sources":94,"claims":183,"safety":261},[95,103,107,111,115,119,124,132,139,145,153,158,163,168,176],{"sourceId":96,"title":97,"canonicalId":98,"canonicalUrl":99,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},"cdc-candidiasis-basics-2024","Candidiasis Basics",null,"https://www.cdc.gov/candidiasis/about/index.html","US Centers for Disease Control and Prevention","regulator","2024-04-24",{"sourceId":104,"title":105,"canonicalId":98,"canonicalUrl":106,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},"cdc-candidiasis-risk-factors-2024","Risk Factors for Candidiasis","https://www.cdc.gov/candidiasis/risk-factors/index.html",{"sourceId":108,"title":109,"canonicalId":98,"canonicalUrl":110,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},"cdc-candidiasis-symptoms-2024","Symptoms of Candidiasis","https://www.cdc.gov/candidiasis/signs-symptoms/index.html",{"sourceId":112,"title":113,"canonicalId":98,"canonicalUrl":114,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},"cdc-candidiasis-testing-2024","Testing and Diagnosis for Candidiasis","https://www.cdc.gov/candidiasis/testing/index.html",{"sourceId":116,"title":117,"canonicalId":98,"canonicalUrl":118,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},"cdc-invasive-candidiasis-overview-2024","Clinical Overview of Invasive Candidiasis","https://www.cdc.gov/candidiasis/hcp/clinical-overview/",{"sourceId":120,"title":121,"canonicalId":98,"canonicalUrl":122,"publisher":100,"sourceType":101,"publicationDate":123,"lastChecked":17},"cdc-candida-auris-clinical-overview-2026","Clinical Overview of Candida auris","https://www.cdc.gov/candida-auris/hcp/clinical-overview/index.html","2026-02-26",{"sourceId":125,"title":126,"canonicalId":127,"canonicalUrl":128,"publisher":129,"sourceType":130,"publicationDate":131,"lastChecked":17},"global-candidiasis-guideline-2025","Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM","doi:10.1016/S1473-3099(24)00749-7","https://doi.org/10.1016/S1473-3099(24)00749-7","European Confederation of Medical Mycology, International Society for Human and Animal Mycology, and American Society for Microbiology","guideline","2025-05-01",{"sourceId":133,"title":134,"canonicalId":135,"canonicalUrl":136,"publisher":137,"sourceType":130,"publicationDate":138,"lastChecked":17},"idsa-candidiasis-guideline-2016","Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America","DOI:10.1093/cid/civ933","https://www.idsociety.org/practice-guideline/candidiasis/","Infectious Diseases Society of America","2016-02-15",{"sourceId":140,"title":141,"canonicalId":98,"canonicalUrl":142,"publisher":143,"sourceType":130,"publicationDate":144,"lastChecked":17},"nih-hiv-mucocutaneous-candidiasis-2026","Candidiasis (Mucocutaneous): Adult and Adolescent Opportunistic Infections Guidelines","https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-opportunistic-infections/candidiasis","US Department of Health and Human Services Panel on Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV","2024-09-16",{"sourceId":146,"title":147,"canonicalId":148,"canonicalUrl":149,"publisher":150,"sourceType":151,"publicationDate":152,"lastChecked":17},"medlineplus-thrush-children-adults-2025","Thrush - children and adults","MedlinePlus Medical Encyclopedia 000626","https://medlineplus.gov/ency/article/000626.htm","U.S. National Library of Medicine","other","2025-08-05",{"sourceId":154,"title":155,"canonicalId":98,"canonicalUrl":156,"publisher":100,"sourceType":101,"publicationDate":157,"lastChecked":17},"cdc-ringworm-clinical-overview-2024","Clinical Overview of Ringworm","https://www.cdc.gov/ringworm/hcp/clinical-overview/index.html","2024-07-15",{"sourceId":159,"title":160,"canonicalId":98,"canonicalUrl":161,"publisher":100,"sourceType":101,"publicationDate":162,"lastChecked":17},"cdc-diabetes-foot-problems-2024","Diabetes Foot Problems: When to See Your Doctor","https://www.cdc.gov/diabetes/communication-resources/diabetes-foot-problems-when-to-see-your-doctor.html","2024-05-15",{"sourceId":164,"title":165,"canonicalId":98,"canonicalUrl":166,"publisher":100,"sourceType":101,"publicationDate":167,"lastChecked":17},"cdc-sepsis-2026","About Sepsis","https://www.cdc.gov/sepsis/about/index.html","2026-03-23",{"sourceId":169,"title":170,"canonicalId":171,"canonicalUrl":172,"publisher":173,"sourceType":174,"publicationDate":175,"lastChecked":17},"911-emergency-us-2023","Calling 911","US emergency telephone service 911","https://www.911.gov/calling-911/","National 911 Program, National Highway Traffic Safety Administration","official-care-service","2023-01-24",{"sourceId":177,"title":178,"canonicalId":179,"canonicalUrl":180,"publisher":181,"sourceType":174,"publicationDate":182,"lastChecked":17},"hrsa-find-health-center-2026","Find a Health Center","HRSA Find a Health Center service","https://findahealthcenter.hrsa.gov/","U.S. Health Resources and Services Administration","2026-07-10",[184,200,214,226,238,248],{"claimId":185,"exactClaim":186,"outcome":187,"population":188,"verdict":189,"evidenceLevel":190,"rationale":191,"safetyStatus":192,"evidenceAsOf":17,"lastUpdated":17,"status":193,"changeHistory":194,"sources":195},"invasive-fungal-risk-context-changes-orientation","Serious invasive candidiasis is concentrated in people who are currently or recently hospitalized or have major host or healthcare risk factors, including critical illness, weakened immunity, cancer treatment or transplantation, invasive devices, recent major surgery, broad antibiotic exposure, kidney failure or dialysis, diabetes, or preterm very-low-birth-weight infancy; these factors raise concern but do not diagnose infection.","recognition of invasive-candidiasis risk context without converting a risk factor into a diagnosis","newborns, children, and adults seeking orientation about possible serious Candida infection, including people with immunocompromise, diabetes, recent hospitalization, or complex medical care","supported","strong","CDC and the current global candidiasis guideline consistently place invasive candidiasis in hospitalized, medically complex, or substantially immunocompromised populations and identify the listed host and healthcare exposures. CDC states that healthy people are generally not at risk. The authorities also require clinical and microbiological assessment, so age, diabetes, or immunocompromise is a modifier rather than proof of infection.","elevated-risk","active",[],[196,197,198,199],{"title":97,"canonicalId":98,"canonicalUrl":99,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":105,"canonicalId":98,"canonicalUrl":106,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":117,"canonicalId":98,"canonicalUrl":118,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":126,"canonicalId":127,"canonicalUrl":128,"publisher":129,"sourceType":130,"publicationDate":131,"lastChecked":17},{"claimId":201,"exactClaim":202,"outcome":203,"population":204,"verdict":189,"evidenceLevel":190,"rationale":205,"safetyStatus":206,"evidenceAsOf":17,"lastUpdated":17,"status":193,"changeHistory":207,"sources":208},"invasive-fungal-symptoms-require-clinical-assessment","Fever, chills, or other systemic illness features cannot by themselves identify invasive candidiasis or its site because manifestations are nonspecific and often occur in people already ill from other conditions; suspected invasive disease requires healthcare assessment and appropriate microbiological testing rather than symptom-based self-diagnosis or self-treatment.","separation of serious systemic-illness orientation from symptom-based diagnosis or self-care","newborns, children, and adults with systemic illness features and concern about invasive Candida infection","CDC describes fever and chills as common but nonspecific, notes that affected patients are often already ill, and identifies blood culture as the primary diagnostic method. The global and IDSA guidelines treat invasive candidiasis as a clinician-managed disease defined by host context, site, cultures, species, and susceptibility rather than a consumer symptom cluster.","do-not-self-use",[],[209,210,211,212,213],{"title":109,"canonicalId":98,"canonicalUrl":110,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":113,"canonicalId":98,"canonicalUrl":114,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":117,"canonicalId":98,"canonicalUrl":118,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":126,"canonicalId":127,"canonicalUrl":128,"publisher":129,"sourceType":130,"publicationDate":131,"lastChecked":17},{"title":134,"canonicalId":135,"canonicalUrl":136,"publisher":137,"sourceType":130,"publicationDate":138,"lastChecked":17},{"claimId":215,"exactClaim":216,"outcome":217,"population":218,"verdict":189,"evidenceLevel":190,"rationale":219,"safetyStatus":192,"evidenceAsOf":17,"lastUpdated":17,"status":193,"changeHistory":220,"sources":221},"unexplained-adult-oral-thrush-needs-risk-assessment","Oral thrush is uncommon in otherwise healthy adults, so a new or unexplained suspected episode should be clinically assessed for confirmation and relevant local, medication, metabolic, or immune risk context rather than assumed to be routine Candida overgrowth or treated as proof of one underlying condition.","confirmation and risk-context assessment for unexplained suspected adult oral thrush without inferring a specific underlying diagnosis","adults with new or unexplained oral changes compatible with thrush and no established cause or current diagnosis","CDC states that mouth and throat candidiasis is uncommon in healthy adults and lists diabetes, HIV/AIDS, cancer, antibiotics, inhaled corticosteroids, dentures, dry mouth, and smoking as relevant contexts. The global guideline and NIH HIV guideline corroborate immune suppression as one important context, while neither supports inferring HIV, diabetes, or another single cause from thrush alone.",[],[222,223,224,225],{"title":105,"canonicalId":98,"canonicalUrl":106,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":113,"canonicalId":98,"canonicalUrl":114,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":126,"canonicalId":127,"canonicalUrl":128,"publisher":129,"sourceType":130,"publicationDate":131,"lastChecked":17},{"title":141,"canonicalId":98,"canonicalUrl":142,"publisher":143,"sourceType":130,"publicationDate":144,"lastChecked":17},{"claimId":227,"exactClaim":228,"outcome":229,"population":230,"verdict":189,"evidenceLevel":190,"rationale":231,"safetyStatus":192,"evidenceAsOf":17,"lastUpdated":17,"status":193,"changeHistory":232,"sources":233},"painful-difficult-swallowing-needs-assessment","Painful or difficult swallowing is compatible with esophageal candidiasis, particularly in an immunocompromised person and sometimes with oral thrush, but it is not Candida-specific and cannot establish the diagnosis without clinical assessment.","recognition of possible esophageal involvement without symptom-based diagnosis","adolescents and adults with painful swallowing, difficult swallowing, or retrosternal discomfort, with or without visible oral thrush or known immune impairment","CDC identifies pain and difficulty swallowing as esophageal-candidiasis features and notes that other infections can cause similar symptoms. The NIH HIV opportunistic-infection guideline gives the strongest population-specific description, linking odynophagia, dysphagia, chest discomfort, low CD4 count, and possible oral thrush while requiring clinical diagnosis and, for definitive confirmation, endoscopic and tissue evidence. The claim therefore supports orientation, not a universal care tier.",[],[234,235,236,237],{"title":97,"canonicalId":98,"canonicalUrl":99,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":109,"canonicalId":98,"canonicalUrl":110,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":141,"canonicalId":98,"canonicalUrl":142,"publisher":143,"sourceType":130,"publicationDate":144,"lastChecked":17},{"title":126,"canonicalId":127,"canonicalUrl":128,"publisher":129,"sourceType":130,"publicationDate":131,"lastChecked":17},{"claimId":239,"exactClaim":240,"outcome":241,"population":242,"verdict":189,"evidenceLevel":190,"rationale":243,"safetyStatus":206,"evidenceAsOf":17,"lastUpdated":17,"status":193,"changeHistory":244,"sources":245},"candida-auris-requires-healthcare-management","Suspected or confirmed Candida auris infection or colonization is a healthcare and infection-control issue, not a self-care condition: symptoms are nonspecific, colonization and infection are distinct, accurate identification requires specialized laboratory methods, and clinical infection treatment requires professional species and susceptibility-guided management.","exclusion of Candida auris infection and colonization from self-diagnosis, self-treatment, and ordinary Candida self-care pathways","children and adults concerned about Candida auris, especially patients who are severely ill, immunocompromised, recently hospitalized, exposed to healthcare facilities, or using invasive medical devices","CDC's 2026 clinical overview distinguishes asymptomatic colonization from clinical infection, describes severe healthcare-associated risk context and nonspecific symptoms, requires sequencing or mass spectrometry for accurate identification, and directs suspected cases into public-health, infection-control, and specialist clinical management. The current global candidiasis guideline corroborates C. auris as an invasive Candida pathogen requiring species-directed management.",[],[246,247],{"title":121,"canonicalId":98,"canonicalUrl":122,"publisher":100,"sourceType":101,"publicationDate":123,"lastChecked":17},{"title":126,"canonicalId":127,"canonicalUrl":128,"publisher":129,"sourceType":130,"publicationDate":131,"lastChecked":17},{"claimId":249,"exactClaim":250,"outcome":251,"population":252,"verdict":189,"evidenceLevel":253,"rationale":254,"safetyStatus":192,"evidenceAsOf":17,"lastUpdated":17,"status":193,"changeHistory":255,"sources":256},"fungal-treatment-worsening-requires-reassessment","New, persistent, spreading, or worsening findings during or after antifungal treatment do not establish resistant or invasive fungal disease and should instead reopen the original diagnosis, body site, organism, host risk, exposure, treatment, adherence, and adverse-effect assessment.","cause-directed reassessment after treatment failure or worsening without inferring resistance, invasion, or treatment success","children and adults with a suspected or diagnosed fungal or Candida-related problem that persists, spreads, recurs, or worsens during or after treatment","moderate","Current candidiasis authorities distinguish infection site, host context, species, susceptibility, initial response, refractory disease, and alternative diagnoses. CDC also notes that fungal conditions are frequently misdiagnosed and that delayed correct treatment can be consequential. Together these sources support reassessment rather than a single inference from nonresponse; they do not establish one universal interval, action, or care tier across conditions and treatments.",[],[257,258,259,260],{"title":97,"canonicalId":98,"canonicalUrl":99,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":113,"canonicalId":98,"canonicalUrl":114,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":126,"canonicalId":127,"canonicalUrl":128,"publisher":129,"sourceType":130,"publicationDate":131,"lastChecked":17},{"title":134,"canonicalId":135,"canonicalUrl":136,"publisher":137,"sourceType":130,"publicationDate":138,"lastChecked":17},[262,275,288,302,313,323],{"safetyId":263,"observableTrigger":264,"careTier":265,"action":266,"applicablePopulations":267,"excludedPopulations":269,"locale":6,"checkedAt":17,"expiresAt":272,"sources":273},"us-pathway-c-routine-care-access","A person needs a nonemergency in-person assessment for a mouth, skin, nail, foot, or possible fungal concern and does not have a regular clinician or dentist.","routine","Use the HRSA Find a Health Center service to locate a nearby federally funded health center, then ask the center whether it provides the needed primary, dental, or referral service.",[268],"people in the United States who need nonemergency assessment and do not have an established care source",[270,271],"people with an immediate medical emergency","people disclosing suicidal thoughts, inability to stay safe, or acute emotional crisis","2026-10-15",[274],{"title":178,"canonicalId":179,"canonicalUrl":180,"publisher":181,"sourceType":174,"publicationDate":182,"lastChecked":17},{"safetyId":276,"observableTrigger":277,"careTier":265,"action":278,"applicablePopulations":279,"excludedPopulations":281,"locale":6,"checkedAt":17,"expiresAt":284,"sources":285},"us-fungal-risk-context-review-routine","A person with cancer treatment, transplant, HIV or another weakened-immune-system condition or therapy develops a possible fungal symptom or an infection being treated is not getting better.","Contact the treating healthcare provider about the symptom, risk context, and whether condition-specific fungal testing or treatment review is needed.",[280],"people in the United States with a weakened immune system or listed high-risk treatment and the observable concern",[282,283],"people without a listed high-risk context","people with sepsis features or another immediate medical emergency","2027-01-15",[286,287],{"title":105,"canonicalId":98,"canonicalUrl":106,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":155,"canonicalId":98,"canonicalUrl":156,"publisher":100,"sourceType":101,"publicationDate":157,"lastChecked":17},{"safetyId":289,"observableTrigger":290,"careTier":291,"action":292,"applicablePopulations":293,"excludedPopulations":295,"locale":6,"checkedAt":17,"expiresAt":284,"sources":298},"us-oral-thrush-high-risk-prompt","A person has thrush-like mouth changes or pain or difficulty swallowing and is living with HIV, receiving chemotherapy, taking immune-suppressing medicine, or otherwise has a weakened immune system.","prompt","Contact the treating healthcare team promptly for assessment and condition-specific testing; do not assume that mouth appearance alone identifies the cause or extent.",[294],"children and adults in the United States with the observable symptom and at least one listed immune-risk context",[296,297],"people without a listed immune-risk context","people who cannot breathe or have another immediate medical emergency",[299,300,301],{"title":147,"canonicalId":148,"canonicalUrl":149,"publisher":150,"sourceType":151,"publicationDate":152,"lastChecked":17},{"title":113,"canonicalId":98,"canonicalUrl":114,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"title":105,"canonicalId":98,"canonicalUrl":106,"publisher":100,"sourceType":101,"publicationDate":102,"lastChecked":17},{"safetyId":303,"observableTrigger":304,"careTier":265,"action":305,"applicablePopulations":306,"excludedPopulations":308,"locale":6,"checkedAt":17,"expiresAt":284,"sources":311},"us-diabetes-foot-change-routine","A person with diabetes notices foot tingling, burning, pain, loss of feeling, a color or temperature change, dry cracked skin, thick yellow toenails, athlete's-foot-like changes between the toes, an ingrown nail, blister, ulcer, or infected corn.","Visit the regular clinician or foot doctor for assessment rather than assuming the change is fungal or treating it without review.",[307],"people in the United States with diabetes and at least one listed foot or nail change",[309,310],"people without diabetes","people with signs of infection plus sepsis features or another immediate medical emergency",[312],{"title":160,"canonicalId":98,"canonicalUrl":161,"publisher":100,"sourceType":101,"publicationDate":162,"lastChecked":17},{"safetyId":314,"observableTrigger":315,"careTier":291,"action":316,"applicablePopulations":317,"excludedPopulations":319,"locale":6,"checkedAt":17,"expiresAt":284,"sources":321},"us-infection-worsening-prompt","A known or suspected infection is not getting better or is getting worse, without the sepsis features or immediate danger listed in the emergency record.","Get medical care immediately and ask the healthcare professional whether emergency-department assessment is needed; do not use a fungal label to explain away worsening.",[318],"children and adults in the United States with the observable worsening or nonresponse",[320],"people with clammy skin, confusion, extreme pain, fever or shivering, a high heart rate or weak pulse, shortness of breath, or another immediate medical emergency",[322],{"title":165,"canonicalId":98,"canonicalUrl":166,"publisher":100,"sourceType":101,"publicationDate":167,"lastChecked":17},{"safetyId":324,"observableTrigger":325,"careTier":326,"action":327,"applicablePopulations":328,"excludedPopulations":330,"locale":6,"checkedAt":17,"expiresAt":272,"sources":332},"us-infection-sepsis-signs-emergency","A person with a known or suspected infection has clammy or sweaty skin, confusion or disorientation, extreme pain or discomfort, fever with shivering or feeling very cold, a high heart rate or weak pulse, or shortness of breath.","emergency","Treat this as a medical emergency: call 911 for immediate assistance or go to the nearest emergency department now, and say that an infection and possible sepsis are concerns.",[329],"children and adults in the United States with a known or suspected infection and at least one listed observable sepsis feature",[331],"people with a stable local symptom and none of the listed emergency features",[333,334],{"title":165,"canonicalId":98,"canonicalUrl":166,"publisher":100,"sourceType":101,"publicationDate":167,"lastChecked":17},{"title":170,"canonicalId":171,"canonicalUrl":172,"publisher":173,"sourceType":174,"publicationDate":175,"lastChecked":17},[336,339,342],{"rel":337,"hreflang":6,"href":338},"alternate","https://candipedia.org/en/symptoms-conditions/serious-fungal-infections/",{"rel":337,"hreflang":340,"href":341},"pl-PL","https://candipedia.org/pl/objawy-i-problemy/ciezkie-zakazenia-grzybicze/",{"rel":337,"hreflang":343,"href":338},"x-default",1784685064867]